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Conversely,studies of individuals who have lost weight and those withanorexia nervosa show that leptin mRNA levels in theiradipose tissue and serum levels of leptin are significantlyreduced. Adiposecells in the intact contralateral fat pad mobilize fat. Metabolic benefits associated withsibutramine-induced weight loss were reported by Krejs et al.22Orlistat has been shown in a few studies to improve individualcomponents of metabolic syndrome in addition to promotingweight loss and mobilizing visceral fat.23,24 The problem withthese drugs continues to be a relatively high rate of sideeffects leading to poor compliance. The ventral and dorsal walls meet at the bladder apex,where the urachus begins its course toward the umbilicus

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